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APC-6000 – Naloxone Injection

If approved, APC-6000 will be a naloxone injection for the treatment of opioid overdose. Adamis intends to develop this product candidate by utilizing the same patented SymjectTM syringe drug delivery platform used in Adamis’ approved SymjepiTM product.


Potential Indication: Opioid Overdose

Naloxone is an opioid antagonist used to treat narcotic overdoses.  Naloxone, which is generally considered the drug of choice for immediate administration for opioid overdose, blocks or reverses the effects of the opioid, including extreme drowsiness, slowed breathing, or loss of consciousness.  Common opioids include morphine, heroin, tramadol, oxycodone, hydrocodone and fentanyl.

According to statistics published by the Centers for Disease Control and Prevention (CDC), in 2017, drug overdoses resulted in approximately 72,000 deaths in the United States – greater than 195 deaths per day.  Drug overdoses are now the leading cause of death for Americans under 50 and the proliferation of more powerful synthetic opioids, like fentanyl and its analogues, could result in future increases in the number of deaths resulting from opioid overdoses.  The current epidemic of drug overdoses is killing people at a faster rate than the HIV epidemic at its peak.